PEA15

PEA15
Identifiers
Aliases	PEA15, HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, phosphoprotein enriched in astrocytes 15, PED-PED/proliferation and apoptosis adaptor protein 15
External IDs	OMIM: 603434; MGI: 104799; GeneCards: PEA15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IZ5, 4IZA, 1N3K,%%s1N3K
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,215,376 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,034,371 bp
RNA expression pattern
	Top expressed in
	dorsal motor nucleus of vagus nerve; ; spinal cord; ; C1 segment; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; internal globus pallidus; ; superior vestibular nucleus; ; external globus pallidus; ; inferior olivary nucleus; ; pars reticulata;
	Top expressed in
	ventricular zone; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; optic nerve; ; cerebellar cortex; ; arcuate nucleus; ; ventromedial nucleus; ; ventral tegmental area; ; median eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; microtubule associated complex; nucleus; cytosol;
Biological process	MAPK cascade; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of apoptotic process; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of glucose import; apoptotic process; carbohydrate transport; DNA damage checkpoint signaling; response to morphine;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8682
	18611
	ENSG00000162734
	ENSMUSG00000013698
	Q15121
	Q62048
	NM_001297576; NM_001297577; NM_001297578; NM_003768
	NM_011063; NM_001329869; NM_001329871; NM_008556
NP_001284505; NP_001284506; NP_001284507; NP_003759; NP_001284506.1;
	NP_003759.1
	NP_001316798; NP_001316800; NP_035193
	Wikidata
View/Edit Human	View/Edit Mouse

Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.^[5]^[6]

AliasesPEA15, HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, phosphoprotein enriched in astrocytes 15, PED-PED/proliferation and apoptosis adaptor protein 15

External IDsOMIM: 603434; MGI: 104799; GeneCards: PEA15

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 1 (human)^[1]

Quick facts Identifiers, Aliases ...

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PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.^[6]

PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.^[7]

[5]

[6]

[1]

[2]

[3]

[4]

[7]

PEA15

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Related Articles

"Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis"

"PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus"

"Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians"

"Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action"

"Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD"