PELI1

PELI1
Identifiers
Aliases	PELI1, pellino E3 ubiquitin protein ligase 1
External IDs	OMIM: 614797; MGI: 1914495; GeneCards: PELI1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	64,144,420 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	21,100,323 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; cartilage tissue; ; mucosa of pharynx; ; amniotic fluid; ; skin of thigh; ; vena cava; ; oral cavity; ; human penis; ; bone marrow; ; epithelium of nasopharynx;
	Top expressed in
	medial ganglionic eminence; ; blood; ; mesenteric lymph nodes; ; left lung lobe; ; transitional epithelium of urinary bladder; ; nucleus accumbens; ; skin of external ear; ; olfactory tubercle; ; Rostral migratory stream; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; ubiquitin-ubiquitin ligase activity; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase activity;
Cellular component	cytosol; nucleus;
Biological process	response to dsRNA; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of cytokine production; protein polyubiquitination; negative regulation of T cell proliferation; response to lipopolysaccharide; positive regulation of B cell proliferation; protein ubiquitination; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of B cell activation; negative regulation of NF-kappaB transcription factor activity; positive regulation of protein ubiquitination; negative regulation of T cell activation; protein phosphorylation; immune response; Toll signaling pathway; protein K48-linked ubiquitination; interleukin-1-mediated signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of necroptotic process; protein K63-linked ubiquitination; regulation of Toll signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57162
	67245
	ENSG00000197329
	ENSMUSG00000020134
	Q96FA3
	Q8C669
	NM_020651
	NM_023324
	NP_065702
	NP_075813
	Wikidata
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