PES1

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesPES1, PES, pescadillo ribosomal biogenesis factor 1, NOP7

External IDsOMIM: 605819; MGI: 1890613; HomoloGene: 5984; GeneCards: PES1; OMA:PES1 - orthologs

Chr.Chromosome 22 (human)^[1]

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PES1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EP8
Identifiers
Aliases	PES1, PES, pescadillo ribosomal biogenesis factor 1, NOP7
External IDs	OMIM: 605819; MGI: 1890613; HomoloGene: 5984; GeneCards: PES1; OMA:PES1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 30,576,625 bp[1] End 30,607,083 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,913,975 bp[2] End 3,930,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve body of pancreas islet of Langerhans skin of leg mucosa of transverse colon skin of abdomen left testis stromal cell of endometrium body of stomach right testis Top expressed in interventricular septum yolk sac spermatocyte ventricular zone neural layer of retina tail of embryo spermatid otic vesicle embryo epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding ribonucleoprotein complex binding Cellular component membrane PeBoW complex chromosome nucleolus condensed chromosome nucleus nucleoplasm cytosol preribosome, large subunit precursor Biological process protein localization to organelle ribosome biogenesis regulation of cell cycle nucleolus organization maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cell population proliferation rRNA processing maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal large subunit biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23481 64934 Ensembl ENSG00000100029 ENSMUSG00000020430 UniProt O00541 Q9EQ61 RefSeq (mRNA) NM_001243225 NM_001282327 NM_001282328 NM_014303 NM_022889 RefSeq (protein) NP_001230154 NP_001269256 NP_001269257 NP_055118 NP_075027 Location (UCSC) Chr 22: 30.58 – 30.61 Mb Chr 11: 3.91 – 3.93 Mb PubMed search [3] [4]
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This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.^[8]