PGAM5

PGAM5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MXO, 3O0T
Identifiers
Aliases	PGAM5, BXLBV68, PGAM family member 5, mitochondrial serine/threonine protein phosphatase
External IDs	OMIM: 614939; MGI: 1919792; HomoloGene: 14597; GeneCards: PGAM5; OMA:PGAM5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	132,722,734 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	110,417,779 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; mucosa of transverse colon; ; muscle of thigh; ; right adrenal gland; ; islet of Langerhans; ; right lobe of liver; ; appendix; ; left adrenal gland; ; right adrenal cortex; ; left adrenal cortex;
	Top expressed in
	superior cervical ganglion; ; endocardial cushion; ; interventricular septum; ; mandibular prominence; ; neural tube; ; medial ganglionic eminence; ; barrel cortex; ; maxillary prominence; ; piriform cortex; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; GTPase activator activity; protein binding; protein-containing complex binding; protein serine/threonine phosphatase activity;
Cellular component	integral component of membrane; membrane; mitochondrion; mitochondrial outer membrane;
Biological process	protein dephosphorylation; necroptosis; programmed cell death; dephosphorylation; positive regulation of GTPase activity; macroautophagy; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	192111
	72542
	ENSG00000247077
	ENSMUSG00000029500
	Q96HS1
	Q8BX10
	NM_138575; NM_001170543; NM_001170544
	NM_001163538; NM_028273
	NP_001164014; NP_001164015; NP_612642
	NP_001157010; NP_082549
	Wikidata
View/Edit Human	View/Edit Mouse

PGAM family member 5 (PGAM5), also known as mitochondrial Serine/threonine-protein phosphatase PGAM5 is related to phosphoglycerate mutase family. It, in humans, is encoded by the PGAM5 gene on chromosome 12.^[5]^[6]