PGAP1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Post-GPI attachment to proteins 1 is a protein that in humans is encoded by the PGAP1 gene.[5]
AliasesPGAP1, Bst1, ISPD3024, MRT42, SPG67, post-GPI attachment to proteins 1, post-GPI attachment to proteins inositol deacylase 1, NEDDSBA
External IDsOMIM: 611655; MGI: 2443342; HomoloGene: 41605; GeneCards: PGAP1; OMA:PGAP1 - orthologs
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| Aliases | PGAP1, Bst1, ISPD3024, MRT42, SPG67, post-GPI attachment to proteins 1, post-GPI attachment to proteins inositol deacylase 1, NEDDSBA | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611655; MGI: 2443342; HomoloGene: 41605; GeneCards: PGAP1; OMA:PGAP1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause of intellectual disability, autosomal recessive 42.
