PGDS

(Hematopoietic) PGDS protein, also known as Glutathione-Dependent PGD Synthase, is a protein that in humans is encoded by the HPGDS gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesHPGDS, GSTS, GSTS1-1, PGD2, PGDS, GSTS1, hematopoietic prostaglandin D synthase

External IDsOMIM: 602598; MGI: 1859384; HomoloGene: 113741; GeneCards: HPGDS; OMA:HPGDS - orthologs

EC number2.5.1.18

Quick facts HPGDS, Available structures ...

HPGDS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IYH, 1IYI, 1V40, 2CVD, 2VCQ, 2VCW, 2VCX, 2VCZ, 2VD0, 2VD1, 3EE2, 3KXO, 3VI5, 3VI7, 4EC0, 4EDY, 4EDZ, 4EE0, 5AIS, 5AIV, 5AIX
Identifiers
Aliases	HPGDS, GSTS, GSTS1-1, PGD2, PGDS, GSTS1, hematopoietic prostaglandin D synthase
External IDs	OMIM: 602598; MGI: 1859384; HomoloGene: 113741; GeneCards: HPGDS; OMA:HPGDS - orthologs
EC number	2.5.1.18
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q22.3 Start 94,298,535 bp[1] End 94,342,876 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C1 Start 65,094,277 bp[2] End 65,121,892 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle placenta Achilles tendon gallbladder synovial membrane amniotic fluid mucosa of transverse colon rectum synovial joint tendon of biceps brachii Top expressed in genital tubercle primordial germ cell calvaria stroma of bone marrow hair Sertoli cell yolk sac ooblast cornea uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity calcium ion binding protein homodimerization activity isomerase activity metal ion binding prostaglandin-D synthase activity protein binding magnesium ion binding glutathione transferase activity Cellular component cytoplasm cytosol Biological process prostaglandin metabolic process locomotory behavior lipid metabolism cyclooxygenase pathway fatty acid metabolic process fatty acid biosynthetic process prostaglandin biosynthetic process glutathione derivative biosynthetic process signal transduction negative regulation of male germ cell proliferation glutathione metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27306 54486 Ensembl ENSG00000163106 ENSMUSG00000029919 UniProt O60760 Q9JHF7 RefSeq (mRNA) NM_014485 NM_019455 RefSeq (protein) NP_055300 NP_062328 Location (UCSC) Chr 4: 94.3 – 94.34 Mb Chr 6: 65.09 – 65.12 Mb PubMed search [3] [4]
Wikidata
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Gluthionine-dependent Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. As a type of Prostaglandin-D synthase, it catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.^[8]