PHKG1

Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKG1 gene.^[5][6]

AliasesPHKG1, PHKG, phosphorylase kinase catalytic subunit gamma 1

External IDsOMIM: 172470; MGI: 97579; GeneCards: PHKG1

Chr.Chromosome 7 (human)^[1]

End56,092,996 bp^[1]

Quick facts Identifiers, Aliases ...

PHKG1
Identifiers
Aliases	PHKG1, PHKG, phosphorylase kinase catalytic subunit gamma 1
External IDs	OMIM: 172470; MGI: 97579; GeneCards: PHKG1
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.1 ↗ ↗ ↗ ↗ 2.7.11.19 ↗ ↗ ↗ ↗ 2.7.11.26 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p11.2 Start 56,080,283 bp[1] End 56,092,996 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G1.3|5 68.26 cM Start 129,892,262 bp[2] End 129,927,390 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh triceps brachii muscle Skeletal muscle tissue of rectus abdominis biceps brachii glutes Skeletal muscle tissue of biceps brachii apex of heart quadriceps femoris muscle vastus lateralis muscle Top expressed in muscle of thigh extensor digitorum longus muscle triceps brachii muscle gastrocnemius muscle masseter muscle medial head of gastrocnemius muscle tibialis anterior muscle vastus lateralis muscle sternocleidomastoid muscle temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding nucleotide binding protein kinase activity protein serine/threonine kinase activity transferase activity tau-protein kinase activity ATP binding calmodulin binding kinase activity phosphorylase kinase activity calmodulin-dependent protein kinase activity Cellular component cytosol phosphorylase kinase complex Biological process protein phosphorylation glycogen biosynthetic process phosphorylation glycogen metabolic process peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction carbohydrate metabolic process glycogen catabolic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 5260 18682 Ensembl ENSG00000164776 ENSMUSG00000025537 UniProt Q16816 P07934 RefSeq (mRNA) NM_001258459 NM_001258460 NM_006213 NM_011079 RefSeq (protein) NP_001245388 NP_001245389 NP_006204 NP_035209 Location (UCSC) Chr 7: 56.08 – 56.09 Mb Chr 5: 129.89 – 129.93 Mb PubMed search [3] [4]
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This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12.^[6]