PHLPP (gene)

PHLPP1
Identifiers
Aliases	PHLPP1, PHLPP, PLEKHE1, SCOP, PPM3A, PH domain and leucine rich repeat protein phosphatase 1
External IDs	OMIM: 609396; MGI: 2138327; HomoloGene: 11015; GeneCards: PHLPP1; OMA:PHLPP1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	62,980,433 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	106,321,980 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; ventricular zone; ; internal globus pallidus; ; middle frontal gyrus; ; inferior ganglion of vagus nerve; ; optic nerve; ; ganglionic eminence; ; buccal mucosa cell; ; Region I of hippocampus proper; ; external globus pallidus;
	Top expressed in
	deep cerebellar nuclei; ; lateral geniculate nucleus; ; globus pallidus; ; substantia nigra; ; medial geniculate nucleus; ; pontine nuclei; ; dorsal tegmental nucleus; ; medial dorsal nucleus; ; mammillary body; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; metal ion binding; protein binding; catalytic activity; hydrolase activity; protein serine/threonine phosphatase activity;
Cellular component	cytosol; membrane; nucleus; cytoplasm; plasma membrane; nuclear membrane; photoreceptor inner segment; photoreceptor outer segment membrane;
Biological process	regulation of apoptotic process; regulation of MAPK cascade; protein dephosphorylation; entrainment of circadian clock; regulation of JNK cascade; regulation of T cell anergy; regulation of p38MAPK cascade; apoptotic process; regulation of protein kinase C signaling; negative regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	23239
	98432
	ENSG00000081913
	ENSMUSG00000044340
	O60346
	Q8CHE4
	NM_194449
	NM_133821
	NP_919431
	NP_598582
	Wikidata
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