PIR (gene)

PDBOrtholog search: PDBe RCSB

AliasesPIR, pirin

External IDsOMIM: 300931; MGI: 1916906; HomoloGene: 2717; GeneCards: PIR; OMA:PIR - orthologs

Chr.X chromosome (human)^[1]

PIR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ERO, 4EWD, 4GUL, 1J1L, 4EWA, 4HLT, 3ACL, 4EWE
Identifiers
Aliases	PIR, pirin
External IDs	OMIM: 300931; MGI: 1916906; HomoloGene: 2717; GeneCards: PIR; OMA:PIR - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 15,384,799 bp[1] End 15,493,564 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F5 Start 163,052,367 bp[2] End 163,156,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment gonad right lung right adrenal gland right adrenal cortex urinary bladder olfactory zone of nasal mucosa left adrenal gland left adrenal cortex islet of Langerhans Top expressed in esophagus lumbar spinal ganglion olfactory epithelium embryo left lobe of liver lip right lung conjunctival fornix transitional epithelium of urinary bladder right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity protein binding transcription coregulator activity dioxygenase activity metal ion binding quercetin 2,3-dioxygenase activity Cellular component cytoplasm nucleus cytosol nucleoplasm Biological process myeloid cell differentiation regulation of transcription, DNA-templated monocyte differentiation transcription by RNA polymerase II transcription, DNA-templated digestion regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8544 69656 Ensembl ENSG00000087842 ENSMUSG00000031379 UniProt O00625 Q9D711 RefSeq (mRNA) NM_003662 NM_001018109 NM_001301402 NM_027153 RefSeq (protein) NP_001018119 NP_003653 NP_001288331 NP_081429 Location (UCSC) Chr X: 15.38 – 15.49 Mb Chr X: 163.05 – 163.16 Mb PubMed search [3] [4]
Wikidata
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Pirin is a protein that in humans is encoded by the PIR gene.^[5][6]

This gene encodes a member of the cupin superfamily. The encoded protein is a Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.^[6]