PLAT domain

In molecular biology the PLAT domain is a protein domain that is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain^[2] or LH2 (Lipoxygenase homology) domain.^[3] The known structure of pancreatic lipase shows this domain binds to procolipase Pfam PF01114, which mediates membrane association.

SymbolPLAT

PfamPF01477

InterProIPR001024

SMARTSM00308

Quick facts Identifiers, Symbol ...

PLAT/LH2 domain
Structure of the lipase-procolipase complex.[1]
Identifiers
Symbol	PLAT
Pfam	PF01477
InterPro	IPR001024
SMART	SM00308
PROSITE	PDOC50095
SCOP2	1lpa / SCOPe / SUPFAM
OPM superfamily	221
OPM protein	3swz
CDD	cd00113
Available protein structures: PDB   IPR001024 PF01477 (ECOD; PDBsum)   AlphaFold IPR001024 PF01477

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This domain forms a beta-sandwich composed of two β-sheets of four β-strands each.^[2][4][5]