PLCD1

PLCD1
Identifiers
Aliases	PLCD1, NDNC3, PLC-III, phospholipase C delta 1
External IDs	OMIM: 602142; MGI: 97614; HomoloGene: 21252; GeneCards: PLCD1; OMA:PLCD1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	38,029,642 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	118,922,570 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; mucosa of transverse colon; ; thoracic diaphragm; ; right testis; ; left testis; ; dorsal motor nucleus of vagus nerve; ; Descending thoracic aorta; ; inferior olivary nucleus; ; ascending aorta; ; gingival epithelium;
	Top expressed in
	esophagus; ; calvaria; ; lip; ; transitional epithelium of urinary bladder; ; membranous bone; ; body of femur; ; ascending aorta; ; corneal stroma; ; Dermatocranium; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activating protein binding; calcium ion binding; phosphatidylinositol phosphate binding; phosphatidylserine binding; signal transducer activity; metal ion binding; phosphatidic acid binding; phosphoric diester hydrolase activity; phospholipase C activity; hydrolase activity; phosphatidylinositol phospholipase C activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding;
Cellular component	cytoplasm; cytosol; plasma membrane; extracellular exosome;
Biological process	intracellular signal transduction; lipid metabolism; labyrinthine layer blood vessel development; inositol phosphate metabolic process; lipid catabolic process; regulation of cell population proliferation; angiogenesis; phospholipid metabolic process; signal transduction; inositol trisphosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	5333
	18799
	ENSG00000187091
	ENSMUSG00000010660
	P51178
	Q8R3B1
	NM_001130964; NM_006225
	NM_001293648; NM_019676
	NP_001124436; NP_006216
	NP_001280577; NP_062650
	Wikidata
View/Edit Human	View/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 is an enzyme that in humans is encoded by the PLCD1 gene.^[5]^[6] PLCd1 is essential to maintain homeostasis of the skin.