PNPLA8

Calcium-independent phospholipase A2-gamma is an enzyme that in humans is encoded by the PNPLA8 gene.^{[5][6][7][8][9]}

AliasesPNPLA8, IPLA2(GAMMA), IPLA2-2, IPLA2G, iPLA2gamma, MMLA, PNPLA-gamma, patatin like phospholipase domain containing 8

External IDsOMIM: 612123; MGI: 1914702; GeneCards: PNPLA8

Chr.Chromosome 7 (human)^[1]

End108,569,666 bp^[1]

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PNPLA8
Identifiers
Aliases	PNPLA8, IPLA2(GAMMA), IPLA2-2, IPLA2G, iPLA2gamma, MMLA, PNPLA-gamma, patatin like phospholipase domain containing 8
External IDs	OMIM: 612123; MGI: 1914702; GeneCards: PNPLA8
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.1.1.5 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.1 Start 108,470,417 bp[1] End 108,569,666 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 B2 Start 44,268,153 bp[2] End 44,369,315 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pancreatic epithelial cell tibialis anterior muscle deltoid muscle entorhinal cortex myocardium of left ventricle pars compacta right ventricle pars reticulata corpus callosum Top expressed in muscle of thigh brown adipose tissue intercostal muscle vastus lateralis muscle temporal muscle myocardium of ventricle sternocleidomastoid muscle triceps brachii muscle mammary gland soleus muscle More reference expression data BioGPS n/a
Gene ontology Molecular function lysophospholipase activity calcium-independent phospholipase A2 activity hydrolase activity ATP binding phospholipase A2 activity Cellular component cytoplasm integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane peroxisomal membrane peroxisome intracellular anatomical structure endoplasmic reticulum perinuclear region of cytoplasm Biological process linoleic acid metabolic process phosphatidylethanolamine acyl-chain remodeling phosphatidylcholine catabolic process lipid metabolism cell death fatty acid metabolic process lipid catabolic process phosphatidylethanolamine catabolic process prostaglandin biosynthetic process metabolism arachidonic acid metabolic process phosphatidylcholine acyl-chain remodeling arachidonic acid secretion Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 50640 67452 Ensembl ENSG00000135241 ENSMUSG00000036257 UniProt Q9NP80 Q8K1N1 RefSeq (mRNA) NM_001256007 NM_001256008 NM_001256009 NM_001256010 NM_001256011 NM_015723 NM_026164 RefSeq (protein) NP_001242936 NP_001242937 NP_001242938 NP_001242939 NP_001242940 NP_056538 NP_080440 Location (UCSC) Chr 7: 108.47 – 108.57 Mb Chr 12: 44.27 – 44.37 Mb PubMed search [3] [4]
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