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POLE4

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.[5]

AliasesPOLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
End74,970,128 bp[1]
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POLE4
Identifiers
AliasesPOLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
External IDsOMIM: 607269; MGI: 1914229; GeneCards: POLE4
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019896

NM_025882
NM_001370295

RefSeq (protein)

NP_063949

NP_080158
NP_001357224

Location (UCSC)Chr 2: 74.96 – 74.97 MbChr 6: 82.6 – 82.68 Mb
PubMed search[3][4]
Wikidata
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Function

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[5]

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