POLR2I

DNA-directed RNA polymerase II subunit RPB9 is an enzyme that in humans is encoded by the POLR2I gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesPOLR2I, RPB9, hRPB14.5, polymerase (RNA) II subunit I, RNA polymerase II subunit I

External IDsOMIM: 180662; MGI: 1917170; HomoloGene: 4541; GeneCards: POLR2I; OMA:POLR2I - orthologs

Chr.Chromosome 19 (human)^[1]

Quick facts Available structures, PDB ...

POLR2I
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IYD, 5IY8, 5IY6, 5IYA, 5IYC, 5IY7, 5IY9, 5IYB
Identifiers
Aliases	POLR2I, RPB9, hRPB14.5, polymerase (RNA) II subunit I, RNA polymerase II subunit I
External IDs	OMIM: 180662; MGI: 1917170; HomoloGene: 4541; GeneCards: POLR2I; OMA:POLR2I - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 36,113,709 bp[1] End 36,115,213 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 29,931,373 bp[2] End 29,932,815 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis muscle of thigh C1 segment apex of heart nucleus accumbens right frontal lobe amygdala right hemisphere of cerebellum putamen Top expressed in internal carotid artery medial ganglionic eminence external carotid artery triceps brachii muscle sternocleidomastoid muscle fossa condyle right kidney embryo neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding nucleic acid binding DNA-directed 5'-3' RNA polymerase activity Cellular component nucleolus RNA polymerase II, core complex nucleus nucleoplasm Biological process mRNA splicing, via spliceosome transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway mRNA cleavage RNA metabolic process regulation of gene silencing by miRNA maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter transcription, DNA-templated somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5438 69920 Ensembl ENSG00000105258 ENSMUSG00000019738 UniProt P36954 P60898 RefSeq (mRNA) NM_006233 NM_027259 RefSeq (protein) NP_006224 NP_081535 Location (UCSC) Chr 19: 36.11 – 36.12 Mb Chr 7: 29.93 – 29.93 Mb PubMed search [3] [4]
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This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.^[6]