POLR3K

DNA-directed RNA polymerase III subunit RPC10 is an enzyme that in humans is encoded by the POLR3K gene.^[5][6][7]

AliasesPOLR3K, C11, C11-RNP3, RPC10, RPC11, RPC12.5, My010, polymerase (RNA) III subunit K, RNA polymerase III subunit K, HLD21

External IDsOMIM: 606007; MGI: 1914255; HomoloGene: 5610; GeneCards: POLR3K; OMA:POLR3K - orthologs

Chr.Chromosome 16 (human)^[1]

End53,608 bp^[1]

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POLR3K
Identifiers
Aliases	POLR3K, C11, C11-RNP3, RPC10, RPC11, RPC12.5, My010, polymerase (RNA) III subunit K, RNA polymerase III subunit K, HLD21
External IDs	OMIM: 606007; MGI: 1914255; HomoloGene: 5610; GeneCards: POLR3K; OMA:POLR3K - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 46,407 bp[1] End 53,608 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 181,506,130 bp[2] End 181,512,623 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon prefrontal cortex gonad biceps brachii thoracic diaphragm Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis monocyte anterior cingulate cortex granulocyte Top expressed in ciliary body retinal pigment epithelium iris medial ganglionic eminence otic placode abdominal wall maxillary prominence mandibular prominence primitive streak urothelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding DNA-directed 5'-3' RNA polymerase activity zinc ion binding metal ion binding RNA polymerase III activity Cellular component RNA polymerase III complex cytosol nucleolus nucleus nucleoplasm Biological process immune system process defense response to virus transcription, DNA-templated transcription by RNA polymerase III innate immune response termination of RNA polymerase III transcription tRNA 3'-trailer cleavage positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51728 67005 Ensembl ENSG00000161980 ENSMUSG00000038628 UniProt Q9Y2Y1 Q9CQZ7 RefSeq (mRNA) NM_016310 NM_025901 RefSeq (protein) NP_057394 NP_080177 Location (UCSC) Chr 16: 0.05 – 0.05 Mb Chr 2: 181.51 – 181.51 Mb PubMed search [3] [4]
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This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes.

The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription.^[7]