PPIH

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesPPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H

External IDsOMIM: 606095; MGI: 106499; HomoloGene: 38172; GeneCards: PPIH; OMA:PPIH - orthologs

Chr.Chromosome 1 (human)^[1]

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PPIH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MZW, 1QOI
Identifiers
Aliases	PPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H
External IDs	OMIM: 606095; MGI: 106499; HomoloGene: 38172; GeneCards: PPIH; OMA:PPIH - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 42,658,335 bp[1] End 42,676,758 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.1|4 55.34 cM Start 119,157,207 bp[2] End 119,177,743 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in embryo ventricular zone ganglionic eminence mucosa of transverse colon granulocyte secondary oocyte rectum mucosa of esophagus olfactory zone of nasal mucosa lymph node Top expressed in ventricular zone embryo spermatocyte embryo yolk sac morula blastocyst spermatid genital tubercle zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribonucleoprotein complex binding isomerase activity protein binding peptidyl-prolyl cis-trans isomerase activity cyclosporin A binding unfolded protein binding Cellular component cytoplasm nuclear speck U4/U6 x U5 tri-snRNP complex spliceosomal complex nucleus nucleoplasm U4/U6 snRNP Biological process mRNA splicing, via spliceosome mRNA processing positive regulation of viral genome replication protein folding RNA splicing protein-containing complex assembly protein peptidyl-prolyl isomerization angiogenesis protein refolding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10465 66101 Ensembl ENSG00000171960 ENSMUSG00000060288 UniProt O43447 Q9D868 RefSeq (mRNA) NM_006347 NM_001330510 NM_001110129 NM_001110130 NM_028677 RefSeq (protein) NP_001317439 NP_006338 NP_001103599 NP_001103600 NP_082953 Location (UCSC) Chr 1: 42.66 – 42.68 Mb Chr 4: 119.16 – 119.18 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.^[7]