PPIL2

Peptidyl-prolyl cis-trans isomerase-like 2 is an enzyme that in humans is encoded by the PPIL2 gene.^[5][6]

AliasesPPIL2, CYC4, CYP60, Cyp-60, UBOX7, hCyP-60, peptidylprolyl isomerase like 2

External IDsOMIM: 607588; MGI: 2447857; GeneCards: PPIL2

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 22 (human)^[1]

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PPIL2
Identifiers
Aliases	PPIL2, CYC4, CYP60, Cyp-60, UBOX7, hCyP-60, peptidylprolyl isomerase like 2
External IDs	OMIM: 607588; MGI: 2447857; GeneCards: PPIL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZKC
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21-q11.22 Start 21,666,000 bp[1] End 21,700,015 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 16,904,419 bp[2] End 16,929,121 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland granulocyte body of pancreas gastric mucosa minor salivary glands apex of heart body of stomach nipple anterior pituitary Top expressed in spermatocyte spermatid genital tubercle tail of embryo ventricular zone thymus neural layer of retina neural tube right kidney granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-ubiquitin ligase activity protein binding isomerase activity ubiquitin protein ligase activity ubiquitin-protein transferase activity transferase activity peptidyl-prolyl cis-trans isomerase activity cyclosporin A binding Cellular component cytoplasm Golgi lumen plasma membrane nucleus nucleoplasm Biological process protein polyubiquitination protein localization to plasma membrane protein folding protein ubiquitination leukocyte migration protein peptidyl-prolyl isomerization Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 23759 66053 Ensembl ENSG00000100023 ENSMUSG00000022771 UniProt Q13356 Q9D787 RefSeq (mRNA) NM_014337 NM_148175 NM_148176 NM_001317996 NM_001252444 NM_001252445 NM_144954 NM_001356386 RefSeq (protein) NP_001304925 NP_055152 NP_680480 NP_680481 NP_001239373 NP_001239374 NP_659203 NP_001343315 Location (UCSC) Chr 22: 21.67 – 21.7 Mb Chr 16: 16.9 – 16.93 Mb PubMed search [3] [4]
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This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]