PPP2R3A

PPP2R3A
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4I5J, 4I5K
Identifiers
Aliases	PPP2R3A, PPP2R3, PR130, PR72, protein phosphatase 2 regulatory subunit B''alpha
External IDs	OMIM: 604944; MGI: 2442104; HomoloGene: 20595; GeneCards: PPP2R3A; OMA:PPP2R3A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	136,147,894 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	101,128,994 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; triceps brachii muscle; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm; ; glutes; ; deltoid muscle; ; body of tongue; ; myocardium of left ventricle;
	Top expressed in
	interventricular septum; ; triceps brachii muscle; ; extraocular muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; vastus lateralis muscle; ; soleus muscle; ; medial head of gastrocnemius muscle; ; tibialis anterior muscle; ; myocardium of ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein-macromolecule adaptor activity; protein binding; metal ion binding; protein phosphatase regulator activity;
Cellular component	protein phosphatase type 2A complex;
Biological process	positive regulation of canonical Wnt signaling pathway; Wnt signaling pathway involved in somitogenesis; protein dephosphorylation; somatic muscle development; eye photoreceptor cell differentiation; positive regulation of protein catabolic process; negative regulation of canonical Wnt signaling pathway; regulation of cell migration involved in somitogenic axis elongation; somite development; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	5523
	235542
	ENSG00000073711
	ENSMUSG00000043154
	Q06190
	n/a
	NM_001190447; NM_002718; NM_181897
	NM_001161362; NM_172144
	NP_001177376; NP_002709; NP_871626
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene.^[5]^[6] Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]