PRDX6

PRDX6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PRX, 5B6N, 5B6M
Identifiers
Aliases	PRDX6, 1-Cys, AOP2, HEL-S-128m, NSGPx, PRX, aiPLA2, p29, peroxiredoxin 6, LPCAT-5
External IDs	OMIM: 602316; MGI: 894320; HomoloGene: 3606; GeneCards: PRDX6; OMA:PRDX6 - orthologs
EC number	1.11.1.9
Gene location (Human)
Chr.	Chromosome 1 (human)
End	173,488,815 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	161,078,789 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; gastrocnemius muscle; ; gastric mucosa; ; amniotic fluid; ; abdominal fat; ; right auricle of heart; ; peritoneum; ; mucosa of transverse colon; ; germinal epithelium; ; rectum;
	Top expressed in
	left colon; ; olfactory epithelium; ; right lung; ; right lung lobe; ; corneal stroma; ; gastrula; ; seminal vesicula; ; superior surface of tongue; ; epiblast; ; left lobe of liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peroxidase activity; catalytic activity; protein binding; peroxiredoxin activity; oxidoreductase activity; hydrolase activity; ubiquitin protein ligase binding; antioxidant activity; cadherin binding; glutathione peroxidase activity; protein homodimerization activity; calcium-independent phospholipase A2 activity; phospholipase A2 activity;
Cellular component	cytoplasm; cytosol; membrane; lysosome; extracellular exosome; extracellular region; extracellular space; azurophil granule lumen; nucleus; perinuclear region of cytoplasm;
Biological process	lipid metabolism; lipid catabolic process; hydrogen peroxide catabolic process; metabolism; cell redox homeostasis; neutrophil degranulation; response to oxidative stress; cellular response to oxidative stress; glycerophospholipid catabolic process; cellular oxidant detoxification; positive regulation of mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	9588
	11758
	ENSG00000117592
	ENSMUSG00000026701
	P30041
	O08709
	NM_004905
	NM_001303408; NM_007453
	NP_004896
	NP_001290337; NP_031479
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene.^[5]^[6] It is a member of the peroxiredoxin family of antioxidant enzymes. Peroxiredoxin 6 is widely distributed in several organs, especially the lungs.^[7]