PRX (gene)

Periaxin is a protein that in humans is encoded by the PRX gene.^[5][6][7]

AliasesPRX, CMT4F, periaxin

External IDsOMIM: 605725; MGI: 108176; GeneCards: PRX

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 19 (human)^[1]

Quick facts Identifiers, Aliases ...

PRX
Identifiers
Aliases	PRX, CMT4F, periaxin
External IDs	OMIM: 605725; MGI: 108176; GeneCards: PRX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CMZ
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 40,393,766 bp[1] End 40,414,793 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 15.91 cM Start 27,196,813 bp[2] End 27,219,639 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb trigeminal ganglion sural nerve spinal ganglia pancreatic ductal cell right lung upper lobe of left lung triceps brachii muscle glutes right lobe of thyroid gland Top expressed in sciatic nerve utricle right lung right lung lobe left lung left lung lobe epithelium of lens ankle vestibular sensory epithelium lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cytoplasm cell junction plasma membrane membrane nucleus T-tubule Biological process axon ensheathment regulation of RNA splicing Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 57716 19153 Ensembl ENSG00000105227 ENSMUSG00000053198 UniProt Q9BXM0 O55103 RefSeq (mRNA) NM_020956 NM_181882 NM_019412 NM_198048 RefSeq (protein) NP_066007 NP_870998 NP_062285 NP_932165 Location (UCSC) Chr 19: 40.39 – 40.41 Mb Chr 7: 27.2 – 27.22 Mb PubMed search [3] [4]
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The PRX gene encodes L- and S-periaxin, proteins of myelinating Schwann cells, and is mutated in Dejerine–Sottas syndrome (MIM 145900) and Charcot–Marie–Tooth disease type 4F (MIM 145900).[supplied by OMIM]^[7]