Prostaglandin D2 synthase
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Prostaglandin-H2 D-isomerase (PTGDS) is an enzyme that in humans is encoded by the PTGDS gene.[5][6]
| PTGDS | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | PTGDS, L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2, prostaglandin D2 synthase | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 176803; MGI: 99261; HomoloGene: 737; GeneCards: PTGDS; OMA:PTGDS - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| EC number | 5.3.99.2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene is a glutathione-independent prostaglandin-D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice over-expressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.[6] Furthermore, PTGDS and its product PGD2 are elevated in the bald-scalp areas of men with male pattern baldness (androgenetic alopecia).[7]
Clinical use
Prostaglandin D2 synthase is used clinically as a diagnostic marker for liquorrhea, that is, to check whether fluid leaking from the nose or ear contains cerebrospinal fluid.[8] This is important in the assessment of head trauma severity. In a medical context, the older term "beta-trace protein" is frequently used to refer to PTGDS.
