PTRF (Cavin1) has been shown to be crucial for caveola formation and function.[7] Deformation caveolae promotes the translocation of cavin-1 from caveolae to the nucleus[8]
Termination of RNA polymerase I catalyzed transcription is a 2-step process that involves pausing of transcription elongation and release of both the pre-ribosomal RNA and Pol I from the DNA template. The pausing is mediated by TTF1 and PTRF.[9][10]
PTRF is a soluble protein containing putative leucine zipper, nuclear localization signal, and PEST domains.[11]
