PTS Mannose-Fructose-Sorbose Family

The structure of the E. coli IIA^Man domain has been shown to exhibit an α/β doubly wound superfold.^[3] The IIB domain also exhibits an α/β doubly wound superfold, but it is very dissimilar from that of the IIA domain.^[4] Instead, it has the same topology as phosphoglyceromutase (PGM). Since both proteins (IIB^Man and PGM) catalyze phosphoryl transfer with a phosphohistidine intermediate, both proteins show a similar distribution of active site residues, and both exhibit similar structures, they are probably homologous.

IIC^Man of E. coli has been reported to have six transmembrane α-helical segments, while IID^Man was reported to have only one.^[5][6] However, hydropathy plots show multiple peaks of hydropathy, rendering the experimental result, suggesting 1 TMS, questionable.^[7] These two proteins together are required for transport, although IIC^Man is presumed to comprise all or most of the sugar transporting channel.

The generalized reaction catalyzed by members of the Man Family is:

Sugar (out) + PEP (in) → Sugar-P (in) + pyruvate (in)

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