PWZ-029

PWZ-029 is a benzodiazepine derivative drug with nootropic effects developed by WiSys,^[1] It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABA_A receptor, acting as a partial inverse agonist at the α₅ subtype and a weak partial agonist at the α₃ subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsant or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.^[2]

CAS Number

• 164025-33-6 ^Y

PubChem CID

• 9971547

ChemSpider

• 8147139 ^N

UNII

• 9D3DS54YCD

Quick facts Identifiers, CAS Number ...

PWZ-029

Identifiers
IUPAC name 8-chloro-3-(methoxymethyl)-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
CAS Number	164025-33-6 Y
PubChem CID	9971547
ChemSpider	8147139 N
UNII	9D3DS54YCD
ChEMBL	ChEMBL45346 N
CompTox Dashboard (EPA)	DTXSID801028421
Chemical and physical data
Formula	C14H14ClN3O2
Molar mass	291.74 g·mol−1
3D model (JSmol)	Interactive image
SMILES ClC1=CC=C2C(C(N(CC3=C(COC)N=CN32)C)=O)=C1
InChI InChI=1S/C14H14ClN3O2/c1-17-6-13-11(7-20-2)16-8-18(13)12-4-3-9(15)5-10(12)14(17)19/h3-5,8H,6-7H2,1-2H3 N Key:FXIDXTIMKAEBGY-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Close