PYLIS downstream sequence

In biology, the PYLIS downstream sequence (PYLIS: pyrrolysine insertion sequence) is a stem-loop structure that appears on some mRNA sequences. This structural motif was previously thought to cause the UAG (amber) stop codon to be translated to the amino acid pyrrolysine instead of ending the protein translation.^[1][2][3] However, it has been shown that PYLIS has no effect upon the efficiency of the UAG suppression,^[4] hence even its name is, in fact, incorrect.

SymbolPYLIS_1

RfamRF01982

RNA typePresumed cis-regulatory element

Domain(s)Archaea and Bacteria

Quick facts Pyrrolysine insertion sequence 1 (mtmB), Identifiers ...

Pyrrolysine insertion sequence 1 (mtmB)
Predicted secondary structure of PYLIS 1 RNA.
Identifiers
Symbol	PYLIS_1
Rfam	RF01982
Other data
RNA type	Presumed cis-regulatory element
Domain(s)	Archaea and Bacteria
PDB structures	PDBe

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