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Padnarsertib

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Drug classNAMPT / PAK4 dual inhibitor
CAS Number
PubChem CID
IUPHAR/BPS
Padnarsertib
Clinical data
Drug classNAMPT / PAK4 dual inhibitor
Identifiers
  • (E)-3-(6-amino-3-pyridinyl)-N-[[5-[4-(4,4-difluoropiperidine-1-carbonyl)phenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC35H29F3N4O3
Molar mass610.637 g·mol−1
3D model (JSmol)
  • C1CN(CCC1(F)F)C(=O)C2=CC=C(C=C2)C3=CC(=C4C(=C3)C=C(O4)CNC(=O)/C=C/C5=CN=C(C=C5)N)C6=CC=C(C=C6)F
  • InChI=1S/C35H29F3N4O3/c36-28-9-7-24(8-10-28)30-19-26(23-3-5-25(6-4-23)34(44)42-15-13-35(37,38)14-16-42)17-27-18-29(45-33(27)30)21-41-32(43)12-2-22-1-11-31(39)40-20-22/h1-12,17-20H,13-16,21H2,(H2,39,40)(H,41,43)/b12-2+
  • Key:MRFOPLWJZULAQD-SWGQDTFXSA-N

Padnarsertib (KPT-9274), is a drug which acts as a dual inhibitor of the enzymes p21-activated kinase 4 (PAK4) and nicotinamide phosphoribosyltransferase (NAMPT). It has potential applications in the treatment of some forms of cancer.[1][2][3][4][5][6][7]

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