Paeonol
Chemical compound
From Wikipedia, the free encyclopedia
Paeonol is a phenolic compound found in peonies[2] such as Paeonia suffruticosa (moutan cortex),[3][4] in Arisaema erubescens,[5] and in Dioscorea japonica.[6] It is a chemical compound found in some traditional Chinese medicines.[7]
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| Names | |
|---|---|
| Preferred IUPAC name
1-(2-Hydroxy-4-methoxyphenyl)ethan-1-one | |
| Other names
2'-Hydroxy-4'-methoxyacetophenone | |
| Identifiers | |
3D model (JSmol) |
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| ChemSpider | |
| ECHA InfoCard | 100.008.194 |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C9H10O3 | |
| Molar mass | 166.176 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Biological effects
A number of biological effects of paeonol in vitro or in animal models have been observed. Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease.[8] Paeonol also reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats.[9]
Paeonol shows antimutagenic activities.[3][6] It also has anti-inflammatory and analgesic effects in carrageenan-evoked thermal hyperalgesia.[10] Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α.[11]
Paeonol has weak MAO-A and MAO-B inhibiting effects with IC50 values of 54.6 μM and 42.5 μM respectively.[12]
Metal complex
Metal complexes of paeonol shows tetrahedral and octahedral coordination geometry in the absence and presence of solvent pyridine respectively.[13]