Iriase served as the principal internal auditor at Bendel State University now Ambrose Alli University Ekpoma (1982–1992) before moving to the corporate world as Area Controller of Omega Bank (1995–1998).
In 1999, Iriase contested and won the Edo State House of Assembly elections where he was elected the Deputy Speaker by members. In 2003, he left to contest for chairman of Owan East Local Government Area and won. He served as the chairman of the Association of Local Governments of Nigeria (ALGON) Edo State Chapter (2003–2007) and later as Vice President, ALGON, Nigeria. He was appointed Secretary to Edo State Government in 2008 and served in that capacity until 2011.
In 2011, Iriase contested in the general elections and won as a member of the House of Representatives, representing Owan East and West Federal Constituency and was re-elected in 2015 serving two four-year terms.[4]
In 2018, he was reportedly expelled from the party by the APC Ward Nine (9) in Owan East Local Government Area of Edo, in a statement issued and signed by Zuberu Shabah and Theophilus Aigboje, its chairman and secretary. The expulsion was however disproved by Sunny Okomayin, the vice chairman of the party in Edo North, saying being a member of the National Executive Committee (NEC) the Ward and Local Council lacks the power to do so.[5][6]