Hamamoto began her career as a civil engineer for Pacific Gas and Electric Company, developing computer models to optimize hydroelectric energy generation in California.
She then worked at GTE Corporation and GTE Hawaiian Tel. During the 1990s, Hamamoto was as an investment banker with Goldman, Sachs & Co. and then at Merrill Lynch & Co, where she was a vice president in Corporate Finance.[3]
When she was tapped by President Obama to serve as an ambassador, she was serving as trustee and advisor to educational institutions in California.[4] Hamamoto served as a campaign bundler and fundraiser for Obama during the 2012 election.[5]
When Hamamoto was sworn in by U.S. Vice President Joe Biden in May 2014, she became the 18th Permanent Representative of the United States of America to the United Nations and Other International Organizations in Geneva. She is the second woman to serve in this position since the 1950s. She resigned in January 2017, after President Trump took office.[6]
Hamamoto is known as a champion of gender equality and the empowerment of women and girls. The U.S. Mission to the United Nations in Geneva has, with her leadership, initiated a program, "The Future She Deserves", to address gender-based violence, adolescent girls' health, economic empowerment and leadership opportunities.[7]