Panadiplon

Panadiplon (U-78875) is an anxiolytic drug with a novel chemical structure that is not closely related to other drugs of this type. It has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and relatively little sedative or amnestic effect, and so is classified as a nonbenzodiazepine anxiolytic.^[1]

ATC code

• none

Legal status

• See Hepatotoxic

CAS Number

• 124423-84-3 ^N

PubChem CID

• 3033821

Quick facts Clinical data, ATC code ...

Panadiplon

Clinical data
ATC code	none
Legal status
Legal status	See Hepatotoxic
Identifiers
IUPAC name 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5 -propan-2-ylimidazo[5,1-c]quinoxalin-4-one
CAS Number	124423-84-3 N
PubChem CID	3033821
ChemSpider	2298411 Y
UNII	V4PW0S7ZP7
KEGG	D05346 Y
ChEMBL	ChEMBL279867 Y
CompTox Dashboard (EPA)	DTXSID40869698
Chemical and physical data
Formula	C18H17N5O2
Molar mass	335.367 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C4N(c5ccccc5n3cnc(c1nc(on1)C2CC2)c34)C(C)C
InChI InChI=1S/C18H17N5O2/c1-10(2)23-13-6-4-3-5-12(13)22-9-19-14(15(22)18(23)24)16-20-17(25-21-16)11-7-8-11/h3-6,9-11H,7-8H2,1-2H3 Y Key:ZGEGOFCLSWVVKG-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Close

Panadiplon acts as a high-affinity GABA_A receptor partial agonist,^[2][3] but despite showing a useful effects profile of a potent anxiolytic with little sedative effects, panadiplon was discontinued from clinical development for use in humans after showing evidence of liver damage in both animals and human trials.^[4][5] Panadiplon however continues to be used in animal research, mainly as a subtype-selective reference drug to compare other GABA_A agonists against.^[6][7]