Paradoxin
Neurotoxic phospholipase
From Wikipedia, the free encyclopedia
Paradoxin (PDX) is a presynaptic neurotoxic phospholipase found in the venom of the inland taipan (Oxyuranus microlepidotus), an extremely venomous species of snake native to Australia.[1]
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Structure
It is similar in structure to another neurotoxin named taipoxin. However they differ in how they are neurotoxic. It is a heterotrimer and composed of three subunits.[2][3]
Toxicity
Relatively little is known about paradoxin including its neuromuscular activity.[1] It is known that paradoxin blocks nerve impulses in the synapses by disrupting and blocking neuromuscular transmission.[4]