Paul J. Hergenrother
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Paul J. Hergenrother is an American chemist and the Kenneth L. Rinehart Jr. Endowed Chair in Natural Products chemistry at the University of Illinois Urbana-Champaign.[1] His research focuses on the development of organic small molecules with novel biological properties such as enzyme inhibitors and activators, chemotherapeutics, and antibacterial agents. In 2008 Hergenrother was awarded the Eli Lilly Award in Biological Chemistry.
Hergenrother attended college at University of Notre Dame. In 1999, Hergenrother earned his PhD in chemistry from the University of Texas, where he worked in the lab of Professor Stephen F. Martin.
Career and research
From 1999 to 2001, Hergenrother completed an American Cancer Society postdoctoral fellowship at Harvard University in the lab of Professor Stuart Schreiber.[2] In 2001, Hergenrother became a faculty member in the department of chemistry at the University of Illinois Urbana-Champaign. In the spring of 2020, he led the team at the University of Illinois that developed a saliva test for SARS-CoV-2,[3] a test that was widely used throughout the covid-19 pandemic.[4] Several notable biologically active compounds have been discovered in his laboratory, including the anticancer drugs PAC-1,[5] deoxynyboquinone,[6][7] everafenib,[8] and ErSO;[9][10] the novel antibiotics lolamicin[11] and fabimycin;[12] and raptinal,[13] a widely used tool in apoptotic research.[14]
Notable papers
Web of Science lists 215 publications authored by Hergenrother in peer-reviewed scientific journals that have been cited over 8000 times.[15] His three most cited research articles have been cited >200 times each.[16][17]
Awards and honors
Source:[1]
- 2002 - National Science Foundation Career Award
- 2003 - Research Corporation Research Innovation Award
- 2003 - Beckman Young Investigator Award
- 2005 - Sloan Research Fellow
- 2006 - GlaxoSmithKline Chemistry Scholar Award
- 2006 - ACS David Robertson Award for Excellence in Medicinal Chemistry[18]
- 2006 - Camille Dreyfus Teacher-Scholar Award
- 2006 - American Cancer Society Research Scholar
- 2008 - Eli Lilly Award in Biological Chemistry[19]
- 2016 - Ehrlich Award for Excellence in Medicinal Chemistry
- 2023 - National Cancer Institute Outstanding Investigator
References
- 1 2 "Paul J. Hergenrother | Chemistry at Illinois". chemistry.illinois.edu. Retrieved 2023-01-07.
- ↑ Kuruvilla, Finny G.; Shamji, Alykhan F.; Sternson, Scott M.; Hergenrother, Paul J.; Schreiber, Stuart L. (2002). "Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays". Nature. 416 (6881): 653–657. Bibcode:2002Natur.416..653K. doi:10.1038/416653a. ISSN 1476-4687. PMID 11948353. S2CID 4424969.
- ↑ Peplow, Mark; C, special to; EN (2025-01-21). "How one university built a COVID-19 screening system". Chemical & Engineering News. Retrieved 2025-12-15.
- ↑ Cotti, Sol. "How U. of I. Turned Its COVID Test Into a Money Maker". Chicago Magazine. Retrieved 2025-12-15.
- ↑ Boudreau, Matthew W.; Peh, Jessie; Hergenrother, Paul J. (2019-11-15). "Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential". ACS Chemical Biology. 14 (11): 2335–2348. doi:10.1021/acschembio.9b00338. ISSN 1554-8937. PMC 6858495. PMID 31260254.
- ↑ Bair, Joseph S.; Palchaudhuri, Rahul; Hergenrother, Paul J. (2010-04-21). "Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death". Journal of the American Chemical Society. 132 (15): 5469–5478. Bibcode:2010JAChS.132.5469B. doi:10.1021/ja100610m. ISSN 1520-5126. PMID 20345134.
- ↑ Lundberg, Alycen P.; Boudreau, Matthew W.; Selting, Kim A.; Chatkewitz, Lindsay E.; Samuelson, Jonathan; Francis, Joshua M.; Parkinson, Elizabeth I.; Barger, Anne M.; Hergenrother, Paul J.; Fan, Timothy M. (August 2021). "Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy". Neoplasia (New York, N.Y.). 23 (8): 811–822. doi:10.1016/j.neo.2021.06.008. ISSN 1476-5586. PMC 8274297. PMID 34246985.
- ↑ Kelly, Aya M.; Berry, Matthew R.; Tasker, Sarah Z.; McKee, Sydney A.; Fan, Timothy M.; Hergenrother, Paul J. (2022-07-13). "Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy". Journal of the American Chemical Society. 144 (27): 12367–12380. Bibcode:2022JAChS.14412367K. doi:10.1021/jacs.2c03944. ISSN 1520-5126. PMC 9612427. PMID 35759775.
- ↑ Boudreau, Matthew W.; Duraki, Darjan; Wang, Lawrence; Mao, Chengjian; Kim, Ji Eun; Henn, Madeline A.; Tang, Bingtao; Fanning, Sean W.; Kiefer, Jeffrey; Tarasow, Theodore M.; Bruckheimer, Elizabeth M.; Moreno, Ramon; Mousses, Spyro; Greene, Geoffrey L.; Roy, Edward J. (2021-07-21). "A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice". Science Translational Medicine. 13 (603) eabf1383. doi:10.1126/scitranslmed.abf1383. ISSN 1946-6242. PMC 8456366. PMID 34290053.
- ↑ Mulligan, Michael P.; Boudreau, Matthew W.; Bouwens, Brooke A.; Lee, Yoongyeong; Carrell, Hunter W.; Zhu, Junyao; Mousses, Spyro; Shapiro, David J.; Nelson, Erik R.; Fan, Timothy M.; Hergenrother, Paul J. (2025-02-26). "Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice". ACS Central Science. 11 (2): 228–238. doi:10.1021/acscentsci.4c01628. ISSN 2374-7943. PMC 11869136. PMID 40028352.
- ↑ Muñoz, Kristen A.; Ulrich, Rebecca J.; Vasan, Archit K.; Sinclair, Matt; Wen, Po-Chao; Holmes, Jessica R.; Lee, Hyang Yeon; Hung, Chien-Che; Fields, Christopher J.; Tajkhorshid, Emad; Lau, Gee W.; Hergenrother, Paul J. (June 2024). "A Gram-negative-selective antibiotic that spares the gut microbiome". Nature. 630 (8016): 429–436. Bibcode:2024Natur.630..429M. doi:10.1038/s41586-024-07502-0. ISSN 1476-4687. PMC 12135874. PMID 38811738.
- ↑ Parker, Erica N.; Cain, Brett N.; Hajian, Behnoush; Ulrich, Rebecca J.; Geddes, Emily J.; Barkho, Sulyman; Lee, Hyang Yeon; Williams, John D.; Raynor, Malik; Caridha, Diana; Zaino, Angela; Shekhar, Mrinal; Muñoz, Kristen A.; Rzasa, Kara M.; Temple, Emily R. (2022-08-24). "An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections". ACS Central Science. 8 (8): 1145–1158. doi:10.1021/acscentsci.2c00598. ISSN 2374-7943. PMC 9413440. PMID 36032774.
- ↑ Palchaudhuri, Rahul; Lambrecht, Michael J.; Botham, Rachel C.; Partlow, Kathryn C.; van Ham, Tjakko J.; Putt, Karson S.; Nguyen, Laurie T.; Kim, Seok-Ho; Peterson, Randall T.; Fan, Timothy M.; Hergenrother, Paul J. (2015-12-01). "A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed". Cell Reports. 13 (9): 2027–2036. doi:10.1016/j.celrep.2015.10.042. ISSN 2211-1247. PMC 4683402. PMID 26655912.
- ↑ Smith, Amanda J.; Hergenrother, Paul J. (2024-08-21). "Raptinal: a powerful tool for rapid induction of apoptotic cell death". Cell Death Discovery. 10 (1): 371. doi:10.1038/s41420-024-02120-1. ISSN 2058-7716. PMC 11335860. PMID 39164225.
- ↑ "Web of Science". Retrieved 7 January 2023.
- ↑ Richter, Michelle F.; Drown, Bryon S.; Riley, Andrew P.; Garcia, Alfredo; Shirai, Tomohiro; Svec, Riley L.; Hergenrother, Paul J. (2017-05-18). "Predictive compound accumulation rules yield a broad-spectrum antibiotic". Nature. 545 (7654): 299–304. Bibcode:2017Natur.545..299R. doi:10.1038/nature22308. ISSN 0028-0836. PMC 5737020. PMID 28489819.
- ↑ Huigens III, Robert W.; Morrison, Karen C.; Hicklin, Robert W.; Flood Jr, Timothy A.; Richter, Michelle F.; Hergenrother, Paul J. (2013). "A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products". Nature Chemistry. 5 (3): 195–202. Bibcode:2013NatCh...5..195H. doi:10.1038/nchem.1549. ISSN 1755-4330. PMC 3965367. PMID 23422561.
- ↑ "The David W. Robertson Award". www.acsmedchem.org. Retrieved 2023-01-07.
- ↑ "Previous Eli Lilly Award in Biological Chemistry Recipients" (PDF). ACS Division of Biological Chemistry. Archived from the original (PDF) on 21 October 2023. Retrieved 7 January 2023.
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