Peanut agglutinin
From Wikipedia, the free encyclopedia
Peanut agglutinin (PNA) is plant lectin protein derived from the fruits of Arachis hypogaea. Peanut agglutinin may also be referred to as Arachis hypogaea lectin. Lectins recognise and bind particular sugar sequences in carbohydrates; peanut agglutinin binds the carbohydrate sequence Gal-β(1-3)-GalNAc. The name "peanut agglutinin" originates from its ability to stick together (agglutinate) cells, such as neuraminidase-treated erythrocytes,[1] which have glycoproteins or glycolipids on their surface which include the Gal-β(1-3)-GalNAc carbohydrate sequence.
| Legume lectin domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the monosaccharide binding site of lentil lectin.[2] | |||||||||
| Identifiers | |||||||||
| Symbol | Lectin_legB | ||||||||
| Pfam | PF00139 | ||||||||
| Pfam clan | CL0004 | ||||||||
| InterPro | IPR001220 | ||||||||
| PROSITE | PDOC00278 | ||||||||
| SCOP2 | 1lem / SCOPe / SUPFAM | ||||||||
| |||||||||
The protein is 273 amino acids in length with the first 23 residues acting as a signal peptide which is subsequently cleaved. It has a Uniprot accession of P02872. There are over 20 structures of this protein in the PDB which reveal and all beta-sheet protein with a tetrameric quaternary structure. It is a member of the Lectin_legB PFAM family.
.svg){kind=small}