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Pelubiprofen

Chemical compound From Wikipedia, the free encyclopedia

Pelubiprofen is a nonsteroidal anti-inflammatory drug of the profen class used to treat back pain and osteoarthritis.[1]

Trade namesPelubi
ATC code
Legal status
  • Rx in several countries
CAS Number
Quick facts Clinical data, Trade names ...
Pelubiprofen
Clinical data
Trade namesPelubi
ATC code
Legal status
Legal status
  • Rx in several countries
Identifiers
  • 2-[4-[(E)-(2-Oxocyclohexylidene)methyl]phenyl]propanoic acid
CAS Number
PubChem CID
DrugBank
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H18O3
Molar mass258.317 g·mol−1
3D model (JSmol)
  • CC(C1=CC=C(C=C1)/C=C/2\CCCCC2=O)C(=O)O
  • InChI=1S/C16H18O3/c1-11(16(18)19)13-8-6-12(7-9-13)10-14-4-2-3-5-15(14)17/h6-11H,2-5H2,1H3,(H,18,19)/b14-10+
  • Key:AUZUGWXLBGZUPP-GXDHUFHOSA-N
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Pelubiprofen was developed in South Korea by Daewon Pharmaceuticals and it is marketed in Korea and Russia,[2] among other countries.

Research

Pelubiprofen is being studied for use in combination with eperisone.[3]

Because pelubiprofen has low water solubility, development of salt formulations with better solubility is being studied.[4]

Synthesis

Pelubiprofen can be prepared by the reaction of 1-(1-piperidino)cyclohexene (1) with ethyl 2-(4-formylphenyl)propanoate (2).[5][6][7][8][9][10][11]

Synthesis of pelubiprofen

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