Pentagestrone acetate
Chemical compound
From Wikipedia, the free encyclopedia
Pentagestrone acetate (PGA), sold under the brand names Gestovis and Gestovister, is a progestin which was described in the literature in 1960 and was introduced by Vister in Italy in 1961.[1][2][3] It is the 3-cyclopentyl enol ether of 17α-hydroxyprogesterone acetate.[4] PGA, along with quingestrone (the 3-cyclopentyl enol ether of progesterone), is said to have very similar properties to those of dydrogesterone, a pure progestogen and close analogue of progesterone.[5]
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| Trade names | Gestovis, Gestovister |
| Other names | PGA; Gestovis; 17α-Acetoxyprogesterone 3-cyclopentyl enol ether |
| Routes of administration | By mouth |
| Drug class | Progestogen; Progestin; Progestogen ether; Progestogen ester |
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| Formula | C28H40O4 |
| Molar mass | 440.624 g·mol−1 |
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PGA is orally active, was provided in 10 and 20 mg capsules, and has been used to treat habitual abortion and menstrual disorders at a dosage of 10 to 20 mg/day.[6] It has been said to have equivalent potency to intramuscular progesterone.[6] The combination of 20 mg/day PGA and 100 μg/day mestranol is an effective ovulation inhibitor in women.[7][8] The effective dosage of PGA in the menstrual delay test has been studied.[9]
Chemistry
PGA, also known as 17α-acetoxyprogesterone 3-cyclopentyl enol ether, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone.[1]
