Peptide 021

Peptide 021 (Ac-DGGL^AG-NH2, P021, GLXC-21260) is a synthetic peptide derivative that is derived from a 4-amino acid active fragment of ciliary neurotrophic factor, which has been substituted with an unnatural adamantane based amino acid residue on the end of the chain. This substitution is highly lipophilic and facilitates transport of the molecule across the blood-brain barrier. It has neurotrophic effects and enhances neurogenesis, and has been investigated for treatment of neurological disorders such as Alzheimer's disease.^{[1][2][3][4][5][6][7]}

CAS Number

• 1246751-68-7

PubChem CID

• 56589645

FormulaC₂₇H₄₂N₆O₈

Molar mass578.667 g·mol⁻¹

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Peptide 021

Identifiers
IUPAC name (3S)-3-acetamido-4-[[2-[[2-[[(2S)-1-[[(5S,7R)-3-carbamoyl-1-adamantyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-oxobutanoic acid
CAS Number	1246751-68-7
PubChem CID	56589645
Chemical and physical data
Formula	C27H42N6O8
Molar mass	578.667 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)C[C@@H](C(=O)NC12C[C@@H]3C[C@H](C1)CC(C3)(C2)C(=O)N)NC(=O)CNC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)C
InChI InChI=1S/C27H42N6O8/c1-14(2)4-18(24(40)33-27-9-16-5-17(10-27)8-26(7-16,13-27)25(28)41)32-21(36)12-29-20(35)11-30-23(39)19(6-22(37)38)31-15(3)34/h14,16-19H,4-13H2,1-3H3,(H2,28,41)(H,29,35)(H,30,39)(H,31,34)(H,32,36)(H,33,40)(H,37,38)/t16-,17+,18-,19-,26?,27?/m0/s1 Key:LUJZBZPLIRWWGJ-NBONATBJSA-N

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