Oxycodone/paracetamol
Pain medication
From Wikipedia, the free encyclopedia
Oxycodone/paracetamol, sold under the brand name Percocet among others,[2] is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.[1]
| Combination of | |
|---|---|
| Oxycodone | Opioid analgesic |
| Acetaminophen | Anilide analgesic |
| Clinical data | |
| Trade names | Percocet, others |
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| License data | |
| Routes of administration | By mouth |
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| Legal status | |
| Legal status |
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| Identifiers | |
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In 2023, it was the 93rd most commonly prescribed medication in the United States, with more than 7 million prescriptions.[3][4]
History
The United States Food and Drug Administration (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.[5]
Society and culture
Percocet is often called perc for short.[6][7] Since the early 2010s, the medication has commonly been name-dropped in songs from multiple genres, such as Future's 2017 song "Mask Off".[6]
Implicated in deaths
In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics[8] be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage.[9]
In December 2009, a study found a fivefold increase in oxycodone-related deaths in Ontario, Canada (mostly accidental) between 1991 and 2007; this led to a doubling of all opioid-related deaths in Ontario over the same period.[10][11][12]
