PhTx-1

Toxic fraction From Wikipedia, the free encyclopedia

PhTx-1 is a toxic fraction isolated from the venom of the Brazilian wandering spider Phoneutria nigriventer.

Composition and Target

PhTx-1 has as its main toxin PnTx-1, with a molecular mass of 8,594.6 Da, composed of 77 aminoacid residues, 14 of which are cysteines.[1] PnTx-1, also known as Tx1, exerts an inhibitory effect on neuronal sodium channels (Nav1.2).[2] This component is considered highly pathogenic for primates.

References

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