Pheniprazine
Chemical compound
From Wikipedia, the free encyclopedia
Pheniprazine, formerly sold under the brand names Catron and Cavodil, is an irreversible and non-selective monoamine oxidase inhibitor (MAOI) of the hydrazine group that was used as an antidepressant to treat depression in the 1960s.[3][4][5][6] It was also used in the treatment of angina pectoris and schizophrenia.[7][8] Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.[9][10][11]
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| Trade names | Catron, Cavodil |
| Other names | Amphetamine hydrazide;[1] α-Methylphenethylhydrazine; JB-516; α-Methylphenelzine; N-Aminoamphetamine |
| Routes of administration | Oral |
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| ECHA InfoCard | 100.000.215 |
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| Formula | C9H14N2 |
| Molar mass | 150.225 g·molâ1 |
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Pharmacology
Pheniprazine is a monoamine oxidase inhibitor (MAOI).[3]
Amphetamine has been detected as an active metabolite of pheniprazine in animals.[12] Pheniprazine produces amphetamine- and psychostimulant-like effects at high doses in animals.[13] The same is true of certain other MAOIs, including iproniazid, phenelzine, tranylcypromine, and pargyline, but not nialamide.[13][14][15]
Chemistry
Pheniprazine, also known as α-methylphenethylhydrazine,[1] is a phenethylamine, amphetamine, and hydrazine derivative.
It is a close analogue of phenelzine (phenethylhydrazine) and amphetamine (α-methylphenethylamine) and can also be referred to by synonyms including amphetamine hydrazide,[1] α-methylphenelzine, and N-aminoamphetamine.
Metfendrazine (α,N-dimethylphenethylhydrazine; N-methylpheniprazine) is the corresponding methamphetamine (N-methylamphetamine) analogue.
Society and culture
Names
Pheniprazine is the generic name of the drug and its INN and BAN.[3] It is also known by the former developmental code name JB-516.[3]