Phenylacetate decarboxylase
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| Phenylacetate decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||
| EC no. | 4.1.1.119 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Phenylacetate decarboxylase is a carboxy-lyase enzyme. The enzyme was isolated from anoxic toluene-producing microbial communities. It is a glycyl radical enzyme.[1][2] It requires activation through a dedicated cognate activating enzyme (encoded by PhdA). The cognate activase catalyses the reductive lysing of S-Adenosyl methionine which yields a 5'-deoxyadenosyl radical that allows the production of the glycyl radical.[3] The enzyme catalyzes the following reaction:
- Phenylacetate + H+ = Toluene + CO2
The enzyme is involved in various biosynthetic and bio-catabolic pathways, including the toluene production pathway, phenylacetate degradation pathway and biosynthetic pathway of select other aromatic compounds in toluene (and other aromatic carbon) producing bacterial species.[4]