Phosphatidylinositol transfer protein
From Wikipedia, the free encyclopedia
 Phosphatidylinositol transfer protein, beta isoform | |||||||||
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | IP_trans | ||||||||
| Pfam | PF02121 | ||||||||
| InterPro | IPR001666 | ||||||||
| SCOP2 | 1fvz / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 138 | ||||||||
| OPM protein | 2a1l | ||||||||
| CDD | cd07815 | ||||||||
| |||||||||
Phosphatidylinositol transfer protein (PITP) or priming in exocytosis protein 3 (PEP3) is a ubiquitous cytosolic domain involved in transport of phospholipids from their site of synthesis in the endoplasmic reticulum and Golgi to other cell membranes.[1][2]
PITP has been also shown to be an essential component of the polyphosphoinositide synthesis machinery and is hence required for proper signalling by epidermal growth factor and f-Met-Leu-Phe, as well as for exocytosis. The role of PITP in polyphosphoinositide synthesis may also explain its involvement in intracellular vesicular traffic.[1]
