Phthalide
Chemical compound
From Wikipedia, the free encyclopedia
Phthalide is an organic chemical compound with the molecular formula C8H6O2. It is a white solid and the simplest benzo lactone. It is prepared from hydroxymethylbenzoic acid.[3]
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 Phthalide Powder | |
| Names | |
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| Preferred IUPAC name
2-Benzofuran-1(3H)-one | |
| Other names
Phthalolactone | |
| Identifiers | |
3D model (JSmol) |
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| ChEBI | |
| ChemSpider | |
| ECHA InfoCard | 100.001.586 |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C8H6O2 | |
| Molar mass | 134.134 g·mol−1 |
| Melting point | 75 to 77 °C (167 to 171 °F; 348 to 350 K)[1] |
| Boiling point | 290 °C (554 °F; 563 K)[2] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Phthalides
The phthalide core is found in a variety of more complex chemical compounds including dyes (such as phenolphthalein), fungicides (such as tetrachlorophthalide, often referred to simply as "phthalide"), and natural oils (such as butylphthalide).
Examples
Phenolphthalein
Tetrachlorophthalide
5-bromophthalide [64169-34-2] is used in the synthesis of Roxadustat and Citalopram.
3-(4'-chlorophenyl)phthalide is a chemical that serves function in the synthesis of Setazindol[4] & Chlortalidone.[5]
Uses
Phthalide has known uses in the synthesis of hydralazine,[5][6] & Pipethiadene.[7][8]
Phthalide is used in the synthesis of dibenzosuberone.