Pierre-Louis Leyssin was the son of François-Louis (died 22 July 1783), Knight of the Order of St. Louis, Baron Domeyssin, co-lord of Culloz and his wife Françoise-Marie de la Martinière.
In the Church, he had a long ecclesiastical career. He received minor orders on 11 March 1742, becomes sub-deacon on 30 March 1743 and deacon on 30 April 1745. He was ordained a priest on 23 December 1747. Doctor of Theology of the Sorbonne in Paris, he received the diaconate of St. noble -Etienne-Saint-Chef Vienna. Vicar-general Jean-Sébastien Barral to Castres bishopric in 1752 he obtained the archdeacon of the Cathedral.
Commendatory of the royal abbey of Saint-Nicolas Septfontaines in the diocese of Reims, he was chosen as vicar general by Claude-Joseph-Mathias Barral, bishop of Troyes. He is member of the Assembly of the clergy of 1765. He was finally appointed archbishop of Embrun on 19 April and confirmed on 15 June 1767. He was consecrated on 5 July by Alexandre Angélique de Talleyrand-Périgord.[3]
[4] He chaired the Dauphiné States from December 1788 to January 1790.