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Poly(A) binding protein interacting protein 2B

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Poly(A) binding protein interacting protein 2B is a protein that in humans is encoded by the PAIP2B gene.[5] It is mainly expressed in the oocytes and fertilized eggs in mice.[6][7]

AliasesPAIP2B, poly(A) binding protein interacting protein 2B
PDBOrtholog search: PDBe RCSB
Quick facts PAIP2B, Identifiers ...
PAIP2B
Identifiers
AliasesPAIP2B, poly(A) binding protein interacting protein 2B
External IDsOMIM: 611018; MGI: 2386865; GeneCards: PAIP2B
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020459

NM_146169

RefSeq (protein)

NP_065192

NP_666281

Location (UCSC)Chr 2: 71.18 – 71.23 MbChr 6: 83.78 – 83.81 Mb
PubMed search[3][4]
Wikidata
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Function

Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors .[8]

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