Zaikov at first worked for the Panov brothers, who also employed Evstratii Delarov. Zaikov departed from Okhotsk in 1772 aboard the Panov vessel Vladimir, staffed with 57 Russians and 10 Yakuts.[1] The winter was spent at the mouth of the Vorovskaya river on the Kamchatka Peninsula, where Vladimir remained until July 1773. Next the vessel went to Medny Island, spending the following year collecting food for the upcoming voyage.[2] On 30 July 1775, Vladimir anchored at Attu Island, spending the following year collecting fur pelts in addition to ferrying 10 men to Agattu Island where they formed an artel for further fur exploitation. Departing from the Near Islands in July 1776, Zaikov reached Unimak Island in August, where he formed his base of operations until May 1778. While on the island, he forced the collection of the Yasak from 89 Aleuts, being later valued at ₽10,684.[2] On the return voyage to Siberia, Zaikov wintered at Umnak Island, and in the following year Agattu was visited to gather the artel men left there. After crossing the Bering Sea, Vladimir reached Okhotsk on 6 September 1779 with 12 men having died during the multi-year voyage.[3] Profits amounted to ₽165,600 on the Okhotsk market, with the animal products primarily being over 3,800 Sea otter skins, almost 4,000 hides from various fox species, 1,725 Northern fur seal skins and 335 Walrus tusks..[2]