Pothos and Leo both followed military careers and reached high office. In ca. 921 Pothos was appointed to the post of Domestic of the Schools by Romanos I (r. 920–944) in succession to Adralestos, who had died recently. A "most handsome and experienced man", according to Theophanes Continuatus, he was sent to counter a Bulgarian invasion into Thrace during the Byzantine–Bulgarian war of 913–927. Pothos led the tagmata of the capital to meet them. Still, a scouting detachment under a certain Michael was ambushed and annihilated. In 922 Pothos was sent to meet another Bulgarian incursion, that had reached Pegae, a suburb of Constantinople. Pothos and John the Rhaiktor commanded the tagmata and the Hetaireia forces, along with fleet elements under Alexios Mosele. The Byzantine army suffered a crushing defeat at the Battle of Pegae in early April 922, losing many dead and captives. Pothos and his brother however managed to escape and find refuge in a nearby fort, while the Bulgarians plundered and burned down the imperial palaces at Pegaea and Stenon. This disaster evidently spelled the end of Pothos' career as Domestic, of whom nothing further is heard during Romanos I's reign.
It is possible, however, that he is to be identified with the strategos of Hellas Pothos, who served in the late 940s. A man of the same name, holding the rank of patrikios and the post of Domestic of the Excubitors, is attested in 958, when he defeated a Magyar raid that had reached the vicinity of Constantinople on 11 April. While some scholars consider the two men to be identical, the prosopographical experts J.-C. Cheynet and J.-F. Vannier regard it unlikely, given that in 921, Pothos' brother was old enough to have a son of marriageable age, and suggest that the commander of 958 was another member of the family, likely the grandson of either Leo or Pothos.