Precorrin-6A reductase
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, precorrin-6A reductase (EC 1.3.1.54) is an enzyme that catalyzes the chemical reaction
| precorrin-6A reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.54 | ||||||||
| CAS no. | 137672-84-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The three substrates of this enzyme are precorrin-6A, reduced nicotinamide adenine dinucleotide phosphate (NADPH) and a proton. Its products are precorrin-6B and oxidised NADP+.[1][2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH=CH group of an acceptor with NAD or NADPH as donor. The systematic name of this enzyme class is precorrin-6B:NADP+ oxidoreductase. Other names in common use include precorrin-6X reductase, precorrin-6Y:NADP+ oxidoreductase and CobK. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in aerobic bacteria.[4]
