Pro-hevein
From Wikipedia, the free encyclopedia
Pro-hevein (Alternative name: Major hevein, gene name: HEV1) is a wound-induced[1] and a lectin-like protein from Hevea brasiliensis (rubber tree) where it is involved in the coagulation of latex.[2]
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| Pro-hevein | |||||||
|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||
| Organism | ? | ||||||
| Symbol | HEV1 | ||||||
| CAS number | 137295-60-4 | ||||||
| UniProt | P02877 | ||||||
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The 187 amino-acid propeptide pro-hevein is cleaved in two fragments: a N-terminal 43 amino-acid Hevein bearing a chitin-binding type-1 domain (also known as CBM18 carbohydrate-binding module) that binds to chitin and a 138 amino-acid Win-like protein bearing a Barwin domain.
It has antifungal properties.[3]
Role of hevein in latex allergy
Hevein is the main IgE-binding epitope of the major latex allergen prohevein[4] as are hevein-like protein domains in fruit class I chitinases.[5] Therefore it is a possible cause for allergen cross-reactivity between latex and banana or other fruits like chestnuts or avocadoes.[6] Hevein-like genes can be found in many plants including Arabidopsis thaliana.[7]
Hevein is called Hev b 6 under the WHO allergen nomenclature.[8][9] There are three entries under this classification, corresponding to the conformational epitopes Hev b 6.01, Hev b 6.03, and Hev b 6.03. They correspond to the full Pro-Havein protein, the matur Hevein (N-terminal), and the C-terminal Barwin domain respectively.[10]