Prokineticin
From Wikipedia, the free encyclopedia
| Prokineticin 1 | |||||||
|---|---|---|---|---|---|---|---|
 Prokineticin 1[1] | |||||||
| Identifiers | |||||||
| Symbol | PROK1 | ||||||
| NCBI gene | 84432 | ||||||
| HGNC | 18454 | ||||||
| OMIM | 606233 | ||||||
| RefSeq | NM_032414 | ||||||
| UniProt | P58294 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p21 | ||||||
| |||||||
| prokineticin 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PROK2 | ||||||
| NCBI gene | 60675 | ||||||
| HGNC | 18455 | ||||||
| OMIM | 607002 | ||||||
| RefSeq | NM_021935 | ||||||
| UniProt | Q9HC23 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p21.1 | ||||||
| |||||||
Prokineticin is a secreted protein that potently contracts gastrointestinal smooth muscle.[2]
Recently, prokineticins have been recognized in humans and other vertebrates.[3] They are thought to be involved in several important physiological processes like neurogenesis, tissue development, angiogenesis, and nociception.[3][4] Other important physiological roles the Bv8/Prokineticins (PKs) are involved in may include cancer, reproduction, and regulating physiological functions that influence circadian rhythms like hormone secretion, ingestive behaviors, and the sleep/wake cycle.[5]
Mutations in the PROK2 (also known as KAL4) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[6] An analysis of DNA from Adolf Hitler found he had a deletion in the PROK2 gene, suggesting he may have had Kallman syndrome.[7]
