Propynyl (drug)
Pharmaceutical compound
From Wikipedia, the free encyclopedia
Propynyl, also known as 4-propynyloxy-3,5-dimethoxyphenethylamine or as propynylscaline, is a psychoactive drug of the scaline family related to mescaline.[1][2][3] It is the derivative of mescaline in which the methoxy group at the 4 position has been replaced with a propynyloxy group.[1][2][3]
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| Other names | PROPYNYL; 4-Propynyloxy-3,5-dimethoxyphenethylamine; Propynylmescaline; Propynylscaline |
| Routes of administration | Oral[1] |
| Drug class | Psychoactive drug |
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| Duration of action | 8–12 hours[1] |
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| Formula | C13H17NO3 |
| Molar mass | 235.283 g·mol−1 |
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In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists propynyl's dose as 80 mg or more orally and its duration as 8 to 12 hours.[1] The effects of propynyl have been reported to include "[not] that much mental stuff", obviously altered behavior, body load, physical fuzziness, cold feet, and next-day hangover or after-effects such as sluggishness.[1] The drug produced no visual changes or closed-eye visuals, and clear hallucinogenic effects were not described.[1] Higher doses than 80 mg orally were not explored, but there was no suggestion of value in exploring higher levels.[1]
The chemical synthesis of propynyl has been described.[1] Analogues of propynyl include mescaline, escaline, proscaline, allylescaline, and methallylescaline, among others.[1][2][3]
Propynyl was first described in the literature by Shulgin in PiHKAL in 1991.[1] It is not a controlled substance in Canada as of 2025.[4]